The 26th edition offers practical, evidence-based recommendations from antimicrobial therapy experts for treating infectious diseases in children. The authors provide commentary for each disease to assist healthcare providers in selecting the most suitable antimicrobial options. Drug descriptions include information on pediatric-appropriate antimicrobial agents and dosing regimens.

New additions in the 26th edition include the first pediatric approval of ceftazidime-avibactam for CRE, replacement antibiotics for cefotaxime, situations favoring ceftaroline over vancomycin for MRSA infections, updates on influenza management with baloxavir approval for children over 12 years, new approaches to mucomycosis treatment, recommendations for malaria, and over 150 new references.

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