Focused on central nervous system (CNS) drug discovery, this book introduces drug researchers to the blood-brain barrier (BBB).​​​​​​​​ ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ to drugs. .
• Written by global experts to provide practical solutions to increase brain penetration or reduce CNS side effects.
• Examine state-of-the-art in silico, in vitro and in vivo tools to assess brain penetration and advanced drug delivery strategies into the CNS.
• Covers BBB anatomy, chemical structure, free drug delivery to the BBB, and transport mechanisms, including passive diffusion, transport/efflux, and receptor-mediated mechanisms.
• Discusses advances in pharmacokinetic and dynamic (PK/PD) and physiological pharmacokinetic (PBPK) models of the BBB.
• Discuss case studies, lessons learned, and approaches to commercializing CNS and non-CNS drugs.