Nearly ten years have passed since the Huntington’s disease gene and its mutation were discovered. During this period, significant progress has been made in our knowledge of the condition. Much more detailed research regarding the actual mechanism by which the HD mutation produces brain pathology has been available since the first two editions were published. There are currently experimental techniques available to advance this research and develop novel therapy strategies.
This well-known book has been completely updated in light of these significant changes. The key recent developments in the neuroscience and genetics of the disease are covered by an international group of leaders in their respective professions. Advances in our comprehension of how the disorder’s genetic basis causes brain degeneration, including comprehensive coverage of transgenic animal models and neurochemical investigations

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