Dr. Tarik F. Massoud, the guest editor of this edition of Neuroimaging Clinics, brings his extensive expertise to the subject of Neuroimaging Anatomy, Part 1: Brain and Skull. Having a thorough understanding of anatomy is crucial in order to minimize both overdiagnosis and misdiagnosis in neuroimaging. This edition is the first part of a two-part series that delves into neuroimaging anatomy, with each article focusing on a specific area of the brain. Additionally, this edition includes an article on Brain Connectomics, which explores the structural and functional connections between cells in the brain. Within this edition, there are 13 pertinent and practice-oriented topics covered, including the anatomy of the cerebral cortex, lobes, and the cerebellum, as well as brainstem anatomy, cranial nerves anatomy, brain functional imaging anatomy, and imaging of normal brain aging, among others. These topics provide comprehensive clinical reviews on the neuroimaging anatomy of the brain and skull, offering practical insights for clinical practice. Under the guidance of experienced editors in the field, this edition presents the most up-to-date information on this timely and focused topic. The authors have synthesized and distilled the latest research and practice guidelines to create clinically significant reviews that are centered around specific topics.