This edition of Neuroimaging Clinics of North America is dedicated to the topic of Brain Embryology and the Cause of Congenital Malformations. It is edited by Drs. Thierry A.G.M. Huisman and Avner Meoded. The articles in this issue will cover a range of subjects, including neuroimaging of normal brain development, ultrasound and MRI of the normal fetal brain, spinal dysraphia, Chiari 2 malformation, unified theory and advances in fetoscopic repair, posterior fossa malformations, synopsis of brain embryology, cerebral dysplasia and overgrowth syndromes, disorders of ventral induction/spectrum of holoprosencephaly, classification and neurogenetics of intracranial vascular anomalies, DTI of brain malformations: exploring the internal architecture, connectomics in brain malformations: how is the malformed brain wired?, commissural anomalies, and more.